W Fraser Symmans Selected Research

Immune Checkpoint Inhibitors

12/2021

Durvalumab with olaparib and paclitaxel for high-risk HER2-negative stage II/III breast cancer: Results from the adaptively randomized I-SPY2 trial.

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W Fraser Symmans Research Topics

Disease

118	Breast Neoplasms (Breast Cancer) 01/2022 - 05/2002
87	Neoplasms (Cancer) 01/2022 - 08/2002
30	Pathologic Complete Response 12/2021 - 06/2005
17	Triple Negative Breast Neoplasms 12/2021 - 03/2008
14	Residual Neoplasm 01/2022 - 04/2004
9	Neoplasm Metastasis (Metastasis) 01/2021 - 05/2002
4	Noninfiltrating Intraductal Carcinoma (DCIS) 01/2020 - 01/2006
3	Inflammatory Breast Neoplasms 01/2021 - 02/2011
2	Neutropenia 01/2018 - 01/2013
2	Carcinoma (Carcinomatosis) 09/2015 - 04/2004
2	Carcinogenesis 11/2009 - 01/2009
1	Genomic Instability 11/2021
1	Neoplasm Micrometastasis 09/2020
1	Fatigue 01/2018
1	Febrile Neutropenia 01/2018

Drug/Important Bio-Agent (IBA)

27	Estrogen ReceptorsIBA 01/2020 - 02/2004
19	Paclitaxel (Taxol)FDA LinkGeneric 12/2021 - 04/2004
16	Hormones (Hormone)IBA 01/2022 - 09/2003
16	Doxorubicin (Adriamycin)FDA LinkGeneric 11/2021 - 01/2003
15	Cyclophosphamide (Cytoxan)FDA LinkGeneric 11/2021 - 04/2003
14	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2003
12	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2003
11	AnthracyclinesIBA 01/2021 - 04/2004
10	Fluorouracil (Carac)FDA LinkGeneric 11/2010 - 04/2003
9	RNA (Ribonucleic Acid)IBA 11/2021 - 10/2002
9	Trastuzumab (Herceptin)FDA Link 11/2021 - 01/2003
9	Messenger RNA (mRNA)IBA 02/2021 - 03/2004
8	Pharmaceutical PreparationsIBA 01/2022 - 07/2004
8	ParaffinIBA 02/2021 - 01/2003
8	Biological ProductsIBA 01/2021 - 08/2003
8	taxaneIBA 01/2021 - 04/2007
8	Tamoxifen FDA LinkGeneric 01/2021 - 04/2007
7	Carboplatin (JM8)FDA LinkGeneric 11/2021 - 07/2016
7	Estrogens (Estrogen)FDA Link 01/2021 - 07/2003
7	human ERBB2 proteinIBA 01/2021 - 03/2008
6	Formaldehyde (Formol)FDA Link 02/2021 - 02/2004
6	ErbB Receptors (EGF Receptor)IBA 01/2020 - 04/2004
6	DNA (Deoxyribonucleic Acid)IBA 04/2014 - 01/2008
5	Progesterone Receptors (Progesterone Receptor)IBA 01/2020 - 03/2008
4	Poly(ADP-ribose) Polymerase InhibitorsIBA 12/2021 - 05/2014
4	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2020 - 01/2008
4	Docetaxel (Taxotere)FDA Link 01/2019 - 01/2003
3	veliparibIBA 11/2021 - 07/2016
3	pertuzumabIBA 11/2021 - 01/2018
3	Ado-Trastuzumab EmtansineIBA 11/2021 - 01/2018
3	Phenobarbital (Luminal)FDA Link 05/2019 - 08/2005
3	Taxoids (Taxanes)IBA 01/2013 - 12/2008
3	Complementary DNA (cDNA)IBA 01/2006 - 03/2003
3	Peptide Hydrolases (Proteases)FDA Link 03/2004 - 03/2003
2	Aromatase InhibitorsIBA 01/2022 - 01/2021
2	Androgen Receptors (Androgen Receptor)IBA 01/2021 - 05/2019
2	TOR Serine-Threonine KinasesIBA 01/2020 - 05/2014
2	Dasatinib (BMS 354825)FDA Link 10/2014 - 05/2010
2	Phosphotransferases (Kinase)IBA 05/2014 - 11/2010
2	Imatinib Mesylate (Gleevec)FDA Link 05/2014 - 10/2004
2	Investigational DrugsIBA 05/2014 - 07/2012
2	Small Interfering RNA (siRNA)IBA 04/2014 - 11/2010
2	Monoclonal AntibodiesIBA 11/2009 - 04/2004
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 04/2009 - 04/2004
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 04/2007 - 06/2005
2	Epirubicin (Ellence)FDA LinkGeneric 01/2007 - 06/2005
2	Hematoxylin (Haematoxylon)IBA 04/2004 - 08/2002
2	Eosine Yellowish-(YS) (Eosin)IBA 04/2004 - 08/2002
2	EnzymesIBA 04/2004 - 01/2003
2	Telomerase (Telomerase Reverse Transcriptase)IBA 03/2004 - 09/2003
2	Cell Adhesion MoleculesIBA 03/2004 - 09/2003
2	Transcription Factors (Transcription Factor)IBA 03/2004 - 09/2003
1	Epidermal Growth Factor (EGF)IBA 01/2022
1	PhosphoproteinsIBA 01/2022
1	Immune Checkpoint InhibitorsIBA 12/2021
1	olaparibIBA 12/2021
1	durvalumabIBA 12/2021
1	PlatinumIBA 11/2021
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 02/2021
1	Estrogen Receptor Modulators (Antiestrogen)IBA 01/2021
1	Folate Receptor 1IBA 01/2021
1	Immunoconjugates (Immunoconjugate)IBA 01/2021
1	mirvetuximab soravtansineIBA 01/2021
1	Estrogen Receptor alphaIBA 01/2021
1	Aurora Kinase AIBA 01/2021
1	Dihydrotestosterone (Androstanolone)IBA 01/2021
1	Estradiol (Delestrogen)FDA LinkGeneric 01/2021
1	Progesterone FDA LinkGeneric 01/2021
1	MK 2206IBA 01/2020
1	pembrolizumabIBA 01/2020
1	Alanine Transaminase (SGPT)IBA 01/2018
1	Cytochrome P-450 CYP2D6 (CYP2D6)IBA 01/2018
1	Cytochrome P-450 CYP2D6 InhibitorsIBA 01/2018
1	4-hydroxy-N-desmethyltamoxifenIBA 01/2018
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2018

Therapy/Procedure

49	Therapeutics 01/2022 - 01/2003
44	Neoadjuvant Therapy 01/2022 - 11/2002
42	Drug Therapy (Chemotherapy) 11/2021 - 08/2002
5	Aftercare (After-Treatment) 01/2018 - 11/2002
4	Adjuvant Chemotherapy 01/2020 - 05/2004
4	Segmental Mastectomy (Lumpectomy) 05/2012 - 09/2006
3	Combination Drug Therapy (Combination Chemotherapy) 01/2012 - 01/2010
2	Lymph Node Excision (Lymph Node Dissection) 09/2020 - 10/2013
2	Precision Medicine 04/2009 - 11/2006
1	Investigational Therapies (Experimental Therapy) 11/2021